5OV2

2'F-ANA-G modified quadruplex with a flipped tetrad

Summary for 5OV2

Entry DOI	10.2210/pdb5ov2/pdb
Related	2LOD 5MCR
NMR Information	BMRB: 34174
Descriptor	artificial quadruplex with propeller, diagonal, and lateral loop (1 entity in total)
Functional Keywords	g-quadruplex, dna, 2'f-ana
Biological source	synthetic construct
Total number of polymer chains	1
Total formula weight	7026.46
Authors	Dickerhoff, J.,Weisz, K. (deposition date: 2017-08-27, release date: 2017-10-18, Last modification date: 2024-05-15)
Primary citation	Dickerhoff, J.,Weisz, K. Nonconventional C-HF Hydrogen Bonds Support a Tetrad Flip in Modified G-Quadruplexes. J Phys Chem Lett, 8:5148-5152, 2017 Cited by PubMed Abstract: A G-quadruplex adopting a (3 + 1)-hybrid structure was substituted at its 5'-tetrad by 2'-deoxy-2'-fluoro-arabinoguanosine (araG) analogs. Incorporation of anti-favoring araG at syn-positions of the 5'-outer tetrad induced a reversal of the tetrad polarity without noticeably compromising the quadruplex stability. This conformational change is shown to be promoted by nonconventional C-H···F hydrogen bonds acting within the anti-araG residues. PubMed: 28976755 DOI: 10.1021/acs.jpclett.7b02428 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation