5OUI

Humanized alpha-AChBP (acetylcholine binding protein) in complex with allosteric binder fragment CU2017

Summary for 5OUI

• Entry DOI: 10.2210/pdb5oui/pdb
• Related: 5afm
• Descriptor: Acetylcholine binding protein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: acetylcholine binding protein, nicotinic acetylcholine receptor, choline-binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 124177.17

Authors

Delbart, F.,Gruss, F.,Ulens, C. (deposition date: 2017-08-23, release date: 2017-11-29, Last modification date: 2024-01-17)

• Primary citation: Delbart, F.,Brams, M.,Gruss, F.,Noppen, S.,Peigneur, S.,Boland, S.,Chaltin, P.,Brandao-Neto, J.,von Delft, F.,Touw, W.G.,Joosten, R.P.,Liekens, S.,Tytgat, J.,Ulens, C.; An allosteric binding site of the alpha 7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein.; J. Biol. Chem., 293:2534-2545, 2018; PubMed: 29237730; DOI: 10.1074/jbc.M117.815316

Experimental method

X-RAY DIFFRACTION (3.1 Å)