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5OTH

The crystal structure of CK2alpha in complex with compound 26

Summary for 5OTH
Entry DOI10.2210/pdb5oth/pdb
DescriptorCasein kinase II subunit alpha, ACETATE ION, PHOSPHATE ION, ... (6 entities in total)
Functional Keywordsck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P68400
Total number of polymer chains2
Total formula weight84279.73
Authors
Brear, P.,De Fusco, C.,Iegre, J.,Yoshida, M.,Mitchell, S.,Rossmann, M.,Carro, L.,Sore, H.,Hyvonen, M.,Spring, D. (deposition date: 2017-08-22, release date: 2018-02-28, Last modification date: 2024-01-17)
Primary citationIegre, J.,Brear, P.,De Fusco, C.,Yoshida, M.,Mitchell, S.L.,Rossmann, M.,Carro, L.,Sore, H.F.,Hyvonen, M.,Spring, D.R.
Second-generation CK2 alpha inhibitors targeting the alpha D pocket.
Chem Sci, 9:3041-3049, 2018
Cited by
PubMed: 29732088
DOI: 10.1039/c7sc05122k
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.69 Å)
Structure validation

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