5ORB

Crystal Structure of BAZ2B bromodomain in complex with 1-methyl-cyclopentapyrazole compound 30

Summary for 5ORB

• Entry DOI: 10.2210/pdb5orb/pdb
• Related: 5OR8 5OR9
• Descriptor: Bromodomain adjacent to zinc finger domain protein 2B, 2-(4-methoxyphenyl)sulfanyl-~{N}-(2-methyl-5,6-dihydro-4~{H}-cyclopenta[c]pyrazol-3-yl)ethanamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: four helical bundle, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q9UIF8
• Total number of polymer chains: 1
• Total formula weight: 13998.13

Authors

Lolli, G.,Dalle Vedove, A.,Marchand, J.-R.,Caflisch, A. (deposition date: 2017-08-15, release date: 2017-09-13, Last modification date: 2024-01-17)

• Primary citation: Marchand, J.R.,Dalle Vedove, A.,Lolli, G.,Caflisch, A.; Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking.; J Chem Inf Model, 57:2584-2597, 2017; PubMed: 28862840; DOI: 10.1021/acs.jcim.7b00336

Experimental method

X-RAY DIFFRACTION (2.103 Å)