5OQW

XIAP in complex with small molecule

Summary for 5OQW

• Entry DOI: 10.2210/pdb5oqw/pdb
• Descriptor: E3 ubiquitin-protein ligase XIAP, ZINC ION, SODIUM ION, ... (5 entities in total)
• Functional Keywords: xiap, protease inhibitor, apoptosis regulation, apoptosis
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 30385.79

Authors

Williams, P.A. (deposition date: 2017-08-14, release date: 2018-06-27, Last modification date: 2019-10-16)

• Primary citation: Ward, G.A.,Lewis, E.J.,Ahn, J.S.,Johnson, C.N.,Lyons, J.F.,Martins, V.,Munck, J.M.,Rich, S.J.,Smyth, T.,Thompson, N.T.,Williams, P.A.,Wilsher, N.E.,Wallis, N.G.,Chessari, G.; ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNF alpha-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.; Mol. Cancer Ther., 17:1381-1391, 2018; PubMed: 29695633; DOI: 10.1158/1535-7163.MCT-17-0848

Experimental method

X-RAY DIFFRACTION (2.31 Å)