5OQW
XIAP in complex with small molecule
Summary for 5OQW
Entry DOI | 10.2210/pdb5oqw/pdb |
Descriptor | E3 ubiquitin-protein ligase XIAP, ZINC ION, SODIUM ION, ... (5 entities in total) |
Functional Keywords | xiap, protease inhibitor, apoptosis regulation, apoptosis |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 30385.79 |
Authors | Williams, P.A. (deposition date: 2017-08-14, release date: 2018-06-27, Last modification date: 2024-05-08) |
Primary citation | Ward, G.A.,Lewis, E.J.,Ahn, J.S.,Johnson, C.N.,Lyons, J.F.,Martins, V.,Munck, J.M.,Rich, S.J.,Smyth, T.,Thompson, N.T.,Williams, P.A.,Wilsher, N.E.,Wallis, N.G.,Chessari, G. ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNF alpha-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth. Mol. Cancer Ther., 17:1381-1391, 2018 Cited by PubMed: 29695633DOI: 10.1158/1535-7163.MCT-17-0848 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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