5ONE

Crystal structure of Aurora-A in complex with FMF-03-145-1 (compound 2)

5ONE の概要

• エントリーDOI: 10.2210/pdb5one/pdb
• 分子名称: Aurora kinase A, 4-(propanoylamino)-~{N}-[4-[(5,8,11-trimethyl-6-oxidanylidene-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]benzamide (3 entities in total)
• 機能のキーワード: aurora kinase, kinase, inhibitor complex, cell cycle, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33484.38

構造登録者

Chaikuad, A.,Ferguson, F.M.,Gray, N.S.,Knapp, S. (登録日: 2017-08-03, 公開日: 2017-09-06, 最終更新日: 2024-01-17)

• 主引用文献: Ferguson, F.M.,Doctor, Z.M.,Chaikuad, A.,Sim, T.,Kim, N.D.,Knapp, S.,Gray, N.S.; Characterization of a highly selective inhibitor of the Aurora kinases.; Bioorg. Med. Chem. Lett., 27:4405-4408, 2017; PubMed: 28818446; DOI: 10.1016/j.bmcl.2017.08.016

実験手法

X-RAY DIFFRACTION (2.6 Å)