5ON2
Quaternary complex of mutant T252A of E. coli leucyl-tRNA synthetase with tRNA(leu), leucyl-adenylate analogue, and post-transfer editing analogue of norvaline in the aminoacylation conformation
Summary for 5ON2
Entry DOI | 10.2210/pdb5on2/pdb |
Related | 5OMW |
Descriptor | Leucine--tRNA ligase, tRNA(leu), ZINC ION, ... (6 entities in total) |
Functional Keywords | reaction catalysed: atp + l-leucine + trna(leu) = amp + diphosphate + l-leucyl-trna(leu) protein translation, aminoacyl-trna activity, leucine-trna ligase, class ia, translation |
Biological source | Escherichia coli (strain K12) More |
Cellular location | Cytoplasm: P07813 |
Total number of polymer chains | 4 |
Total formula weight | 256906.45 |
Authors | Palencia, A.,Cusack, S. (deposition date: 2017-08-02, release date: 2017-11-15, Last modification date: 2024-01-17) |
Primary citation | Dulic, M.,Cvetesic, N.,Zivkovic, I.,Palencia, A.,Cusack, S.,Bertosa, B.,Gruic-Sovulj, I. Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase. J. Mol. Biol., 430:1-16, 2018 Cited by PubMed: 29111343DOI: 10.1016/j.jmb.2017.10.024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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