5ON2

Quaternary complex of mutant T252A of E. coli leucyl-tRNA synthetase with tRNA(leu), leucyl-adenylate analogue, and post-transfer editing analogue of norvaline in the aminoacylation conformation

5ON2 の概要

• エントリーDOI: 10.2210/pdb5on2/pdb
• 関連するPDBエントリー: 5OMW
• 分子名称: Leucine--tRNA ligase, tRNA(leu), ZINC ION, ... (6 entities in total)
• 機能のキーワード: reaction catalysed: atp + l-leucine + trna(leu) = amp + diphosphate + l-leucyl-trna(leu) protein translation, aminoacyl-trna activity, leucine-trna ligase, class ia, translation
• 由来する生物種: Escherichia coli (strain K12); 詳細
• 細胞内の位置: Cytoplasm: P07813
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 256906.45

構造登録者

Palencia, A.,Cusack, S. (登録日: 2017-08-02, 公開日: 2017-11-15, 最終更新日: 2024-01-17)

• 主引用文献: Dulic, M.,Cvetesic, N.,Zivkovic, I.,Palencia, A.,Cusack, S.,Bertosa, B.,Gruic-Sovulj, I.; Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.; J. Mol. Biol., 430:1-16, 2018; PubMed: 29111343; DOI: 10.1016/j.jmb.2017.10.024

実験手法

X-RAY DIFFRACTION (3.1 Å)