5OJJ
Crystal structure of the Zn-bound ubiquitin-conjugating enzyme Ube2T
Summary for 5OJJ
Entry DOI | 10.2210/pdb5ojj/pdb |
Descriptor | Ubiquitin-conjugating enzyme E2 T, ACETATE ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | ubiquitin conjugating enzyme, zinc, domain swap, oligomer, ligase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q9NPD8 |
Total number of polymer chains | 6 |
Total formula weight | 107240.64 |
Authors | Morreale, F.E.,Testa, A.,Chaugule, V.K.,Bortoluzzi, A.,Ciulli, A.,Walden, H. (deposition date: 2017-07-21, release date: 2017-10-04, Last modification date: 2024-01-17) |
Primary citation | Morreale, F.E.,Testa, A.,Chaugule, V.K.,Bortoluzzi, A.,Ciulli, A.,Walden, H. Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements. J. Med. Chem., 60:8183-8191, 2017 Cited by PubMed: 28933844DOI: 10.1021/acs.jmedchem.7b01071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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