5OJ1

Penicillin Binding Protein 2x (PBP2x) from S.pneumoniae in complex with Oxacillin and a tetrasaccharide

5OJ1 の概要

• エントリーDOI: 10.2210/pdb5oj1/pdb
• 分子名称: Penicillin-binding protein 2X, (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: penicillin-binding-protein, cell-wall, antibiotic
• 由来する生物種: Streptococcus pneumoniae R6
• 細胞内の位置: Cell membrane; Single-pass membrane protein: P59676
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 77234.41

構造登録者

Bernardo-Garcia, N.,Hermoso, J.A. (登録日: 2017-07-20, 公開日: 2018-05-30, 最終更新日: 2024-01-17)

• 主引用文献: Bernardo-Garcia, N.,Mahasenan, K.V.,Batuecas, M.T.,Lee, M.,Hesek, D.,Petrackova, D.,Doubravova, L.,Branny, P.,Mobashery, S.,Hermoso, J.A.; Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae.; ACS Chem. Biol., 13:694-702, 2018; PubMed: 29357220; DOI: 10.1021/acschembio.7b00817

実験手法

X-RAY DIFFRACTION (2.85 Å)