5OI5

Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1

5OI5 の概要

• エントリーDOI: 10.2210/pdb5oi5/pdb
• 関連するPDBエントリー: 4LH4
• 分子名称: Integrase, (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-2-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: hiv-1, integrase, catalytic core domain, viral protein
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20577.52

構造登録者

Ruff, M.,Benarous, R. (登録日: 2017-07-18, 公開日: 2018-03-07, 最終更新日: 2024-01-17)

• 主引用文献: Bonnard, D.,Le Rouzic, E.,Eiler, S.,Amadori, C.,Orlov, I.,Bruneau, J.M.,Brias, J.,Barbion, J.,Chevreuil, F.,Spehner, D.,Chasset, S.,Ledoussal, B.,Moreau, F.,Saib, A.,Klaholz, B.P.,Emiliani, S.,Ruff, M.,Zamborlini, A.,Benarous, R.; Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.; J. Biol. Chem., 293:6172-6186, 2018; PubMed: 29507092; DOI: 10.1074/jbc.M117.816793

実験手法

X-RAY DIFFRACTION (2.4 Å)