4LH4

Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration

Summary for 4LH4

• Entry DOI: 10.2210/pdb4lh4/pdb
• Related: 1BHL 4LH5
• Descriptor: Integrase, MAGNESIUM ION (3 entities in total)
• Functional Keywords: integrase, transferase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 20163.95

Authors

Ruff, M.,Levy, N.,Eiler, S. (deposition date: 2013-06-30, release date: 2013-12-25, Last modification date: 2023-09-20)

• Primary citation: Le Rouzic, E.,Bonnard, D.,Chasset, S.,Bruneau, J.M.,Chevreuil, F.,Le Strat, F.,Nguyen, J.,Beauvoir, R.,Amadori, C.,Brias, J.,Vomscheid, S.,Eiler, S.,Levy, N.,Delelis, O.,Deprez, E.,Saib, A.,Zamborlini, A.,Emiliani, S.,Ruff, M.,Ledoussal, B.,Moreau, F.,Benarous, R.; Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.; Retrovirology, 10:144-144, 2013; PubMed: 24261564; DOI: 10.1186/1742-4690-10-144

Experimental method

X-RAY DIFFRACTION (1.8 Å)