5OI5

Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0015074	biological_process	DNA integration

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 9VK A 501

Chain	Residue
A	GLN95
A	HOH606
A	THR124
A	THR125
A	ALA128
A	TRP132
A	ALA169
A	GLU170
A	HIS171
A	THR174

---

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 502

Chain	Residue
A	LYS71
A	HIS171

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP64
A	ASP116

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P04585

Chain	Residue	Details
A	GLU152

---