5OHJ

Human phosphodiesterase 4B catalytic domain in complex with a pyrrolidinyl inhibitor.

5OHJ の概要

• エントリーDOI: 10.2210/pdb5ohj/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: human phosphodiesterase 4b, hydrolase, pyrrolidinyl inhibitor, pde4b
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98524.02

構造登録者

Rizzi, A.,Carzaniga, L.,Armani, E. (登録日: 2017-07-17, 公開日: 2017-12-13, 最終更新日: 2024-05-01)

• 主引用文献: Carzaniga, L.,Amari, G.,Rizzi, A.,Capaldi, C.,De Fanti, R.,Ghidini, E.,Villetti, G.,Carnini, C.,Moretto, N.,Facchinetti, F.,Caruso, P.,Marchini, G.,Battipaglia, L.,Patacchini, R.,Cenacchi, V.,Volta, R.,Amadei, F.,Pappani, A.,Capacchi, S.,Bagnacani, V.,Delcanale, M.,Puccini, P.,Catinella, S.,Civelli, M.,Armani, E.; Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases.; J. Med. Chem., 60:10026-10046, 2017; PubMed: 29200281; DOI: 10.1021/acs.jmedchem.7b01044

実験手法

X-RAY DIFFRACTION (1.6 Å)