5OFB
Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation S87L
Summary for 5OFB
Entry DOI | 10.2210/pdb5ofb/pdb |
Descriptor | MORC family CW-type zinc finger protein 2, ZINC ION, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | ghkl atpase, chromatin remodeler, epigenetic silencing, transcriptional repressor, coiled-coil, cw domain, dna binding protein, charcot-marie-tooth disease, spinal muscular atrophy, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 141308.25 |
Authors | Douse, C.H.,Liu, Y.,Modis, Y. (deposition date: 2017-07-10, release date: 2018-02-14, Last modification date: 2024-05-01) |
Primary citation | Douse, C.H.,Bloor, S.,Liu, Y.,Shamin, M.,Tchasovnikarova, I.A.,Timms, R.T.,Lehner, P.J.,Modis, Y. Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Nat Commun, 9:651-651, 2018 Cited by PubMed: 29440755DOI: 10.1038/s41467-018-03045-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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