5OF0

X-ray structure of human glutamate carboxypeptidase II (GCPII), the E424M inactive mutant, in complex with a inhibitor CFBzOG

Summary for 5OF0

Entry DOI	10.2210/pdb5of0/pdb
Descriptor	Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; urea based inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	83639.71
Authors	Novakova, Z.,Motlova, L.,Barinka, C. (deposition date: 2017-07-10, release date: 2018-08-01, Last modification date: 2024-01-17)
Primary citation	Nakajima, R.,Novakova, Z.,Tueckmantel, W.,Motlova, L.,Barinka, C.,Kozikowski, A.P. 2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands for Potential Use as Theranostics. ACS Med Chem Lett, 9:1099-1104, 2018 Cited by PubMed: 30429952 DOI: 10.1021/acsmedchemlett.8b00318 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation