5OEW
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with glutamate and positive allosteric modulator BPAM538
Summary for 5OEW
Entry DOI | 10.2210/pdb5oew/pdb |
Descriptor | Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ... (6 entities in total) |
Functional Keywords | ionotropic glutamate receptor glua2. ligand-binding domain, positive allosteric modulator, membrane protein |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P19491 |
Total number of polymer chains | 3 |
Total formula weight | 90318.51 |
Authors | Larsen, A.P.,Frydenvang, K.A.,Kastrup, J.S. (deposition date: 2017-07-10, release date: 2018-01-03, Last modification date: 2024-01-17) |
Primary citation | Goffin, E.,Drapier, T.,Larsen, A.P.,Geubelle, P.,Ptak, C.P.,Laulumaa, S.,Rovinskaja, K.,Gilissen, J.,Tullio, P.,Olsen, L.,Frydenvang, K.,Pirotte, B.,Hanson, J.,Oswald, R.E.,Kastrup, J.S.,Francotte, P. 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. J. Med. Chem., 61:251-264, 2018 Cited by PubMed: 29256599DOI: 10.1021/acs.jmedchem.7b01323 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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