5ODX

Crystal Structure of Hsp90-alpha N-Domain in complex with Indazole derivative

Summary for 5ODX

Entry DOI	10.2210/pdb5odx/pdb
Descriptor	Heat shock protein HSP 90-alpha, 3-[(3~{S})-3-methoxypiperidin-1-yl]carbonyl-~{N}-methyl-~{N}-(4-morpholin-4-ylphenyl)-6-oxidanyl-1~{H}-indazole-5-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	chaperone
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	26363.64
Authors	Amaral, M.,Schuetz, D. (deposition date: 2017-07-07, release date: 2018-04-18, Last modification date: 2024-05-08)
Primary citation	Schuetz, D.A.,Richter, L.,Amaral, M.,Grandits, M.,Gradler, U.,Musil, D.,Buchstaller, H.P.,Eggenweiler, H.M.,Frech, M.,Ecker, G.F. Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors. J. Med. Chem., 61:4397-4411, 2018 Cited by PubMed: 29701469 DOI: 10.1021/acs.jmedchem.8b00080 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation