5OCK

Crystal structure of ACPA E4 in complex with CEP1

5OCK の概要

• エントリーDOI: 10.2210/pdb5ock/pdb
• 分子名称: Human ACPA E4 Fab fragment - Light chain, Human ACPA E4 Fab fragment - Heavy chain, CEP1 peptide (from enolase), ... (4 entities in total)
• 機能のキーワード: anti-citrullinated protein antibody fab fragment, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49482.07

構造登録者

Dobritzsch, D.,Ge, C.,Holmdahl, R. (登録日: 2017-07-03, 公開日: 2018-07-04, 最終更新日: 2024-11-06)

主引用文献

Ge, C.,Xu, B.,Liang, B.,Lonnblom, E.,Lundstrom, S.L.,Zubarev, R.A.,Ayoglu, B.,Nilsson, P.,Skogh, T.,Kastbom, A.,Malmstrom, V.,Klareskog, L.,Toes, R.E.M.,Rispens, T.,Dobritzsch, D.,Holmdahl, R.
Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71:210-221, 2019

PubMed Abstract: Anti-citrullinated protein antibodies (ACPAs) develop many years before the clinical onset of rheumatoid arthritis (RA). This study was undertaken to address the molecular basis of the specificity and cross-reactivity of ACPAs from patients with RA.

PubMed: 30152126
DOI: 10.1002/art.40698

実験手法

X-RAY DIFFRACTION (1.6 Å)