5OCI

Human Heat Shock Protein 90 bound to 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide

Summary for 5OCI

• Entry DOI: 10.2210/pdb5oci/pdb
• Descriptor: Heat shock protein HSP 90-alpha, 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide (3 entities in total)
• Functional Keywords: heat-shock protein complex, hsp90, atpase, pyrazole, chaperone, atp-binding, heat shock, nucleotide-binding, phosphorylation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 26170.36

Authors

Schuetz, D.A.,Richter, L.,Amaral, M.,Grandits, M.,Musil, D.,Graedler, U.,Frech, M.,Ecker, G.F. (deposition date: 2017-07-03, release date: 2018-05-23, Last modification date: 2019-10-16)

• Primary citation: Schuetz, D.A.,Richter, L.,Amaral, M.,Grandits, M.,Gradler, U.,Musil, D.,Buchstaller, H.P.,Eggenweiler, H.M.,Frech, M.,Ecker, G.F.; Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.; J. Med. Chem., 61:4397-4411, 2018; PubMed: 29701469; DOI: 10.1021/acs.jmedchem.8b00080

Experimental method

X-RAY DIFFRACTION (1.62 Å)