5OBJ
Aurora A kinase in complex with 2-(3-fluorophenyl)quinoline-4-carboxylic acid and ATP
Summary for 5OBJ
Entry DOI | 10.2210/pdb5obj/pdb |
Descriptor | Aurora kinase A, MAGNESIUM ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | inhibitor, kinase, allostery, protein-protein interface, cell cycle |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
Total number of polymer chains | 1 |
Total formula weight | 32375.26 |
Authors | Rossmann, M.,Janecek, M.,Hyvonen, M. (deposition date: 2017-06-28, release date: 2017-08-09, Last modification date: 2024-05-08) |
Primary citation | Cole, D.J.,Janecek, M.,Stokes, J.E.,Rossmann, M.,Faver, J.C.,McKenzie, G.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R.,Huggins, D.J.,Jorgensen, W.L. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction. Chem. Commun. (Camb.), 53:9372-9375, 2017 Cited by PubMed: 28787041DOI: 10.1039/c7cc05379g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.901 Å) |
Structure validation
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