5OBH

Crystal structure of glycine binding protein in complex with bicuculline

Summary for 5OBH

• Entry DOI: 10.2210/pdb5obh/pdb
• Related PRD ID: PRD_900017
• Descriptor: Soluble acetylcholine receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium, ... (6 entities in total)
• Functional Keywords: receptor, acetylcholine binding, signaling protein
• Biological source: Aplysia californica (California sea hare)
• Total number of polymer chains: 5
• Total formula weight: 144707.61

Authors

Dawson, A.,Hunter, W.N.,Jones, M. (deposition date: 2017-06-27, release date: 2018-08-01, Last modification date: 2024-01-17)

• Primary citation: Jones, M.J.,Dawson, A.,Hales, T.G.,Hunter, W.N.; A Structural Rationale for N-Methylbicuculline Acting as a Promiscuous Competitive Antagonist of Inhibitory Pentameric Ligand-Gated Ion Channels.; Chembiochem, 21:1526-1533, 2020; PubMed: 31859406; DOI: 10.1002/cbic.201900680

Experimental method

X-RAY DIFFRACTION (2.4 Å)