5OAX

Galectin-3c in complex with thiogalactoside derivate

Summary for 5OAX

• Entry DOI: 10.2210/pdb5oax/pdb
• Related: 4BLI
• Descriptor: Galectin-3, 5,6-bis(fluoranyl)-3-[[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]chromen-2-one (3 entities in total)
• Functional Keywords: sugar binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 16432.76

Authors

Nilsson, U.J.,Peterson, K.,Hakansson, M.,Logan, D.T. (deposition date: 2017-06-25, release date: 2018-05-02, Last modification date: 2019-10-16)

• Primary citation: Peterson, K.,Kumar, R.,Stenstrom, O.,Verma, P.,Verma, P.R.,Hakansson, M.,Kahl-Knutsson, B.,Zetterberg, F.,Leffler, H.,Akke, M.,Logan, D.T.,Nilsson, U.J.; Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.; J. Med. Chem., 61:1164-1175, 2018; PubMed: 29284090; DOI: 10.1021/acs.jmedchem.7b01626

Experimental method

X-RAY DIFFRACTION (1.2 Å)