5OA4
Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AsqJ_V72I mutant in complex with 4-methoxycyclopeptin (1)
Summary for 5OA4
| Entry DOI | 10.2210/pdb5oa4/pdb |
| Related | 5DAP |
| Descriptor | Iron/alpha-ketoglutarate-dependent dioxygenase asqJ, NICKEL (II) ION, (3S)-3-(4-methoxybenzyl)-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione, ... (6 entities in total) |
| Functional Keywords | antibiotics, quinolone biosynthesis, molecular engineering, desaturase, catalytic mechanism, mutagenesis, pi-stacking, oxidoreductase |
| Biological source | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) |
| Total number of polymer chains | 1 |
| Total formula weight | 34519.52 |
| Authors | Groll, M.,Braeuer, A.,Kaila, V.R.I. (deposition date: 2017-06-20, release date: 2018-04-04, Last modification date: 2024-01-17) |
| Primary citation | Mader, S.L.,Brauer, A.,Groll, M.,Kaila, V.R.I. Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ. Nat Commun, 9:1168-1168, 2018 Cited by PubMed: 29563492DOI: 10.1038/s41467-018-03442-2 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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