5O9A

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504Y-N775S) in complex with glutamate and BPAM121 at 1.78 A resolution

5O9A の概要

• エントリーDOI: 10.2210/pdb5o9a/pdb
• 分子名称: Glutamate receptor 2,Glutamate receptor 2, SULFATE ION, 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, ... (10 entities in total)
• 機能のキーワード: ampa receptor, ligand-binding domain, positive allosteric modulator, membrane protein, signaling protein, ionotropic glutamate receptor, glua2, glur2, l504y-n775s
• 由来する生物種: Rattus norvegicus (Norway Rat); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P19491
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 121368.12

構造登録者

Laulumaa, S.,Rovinskaja, K.,Frydenvang, K.A.,Kastrup, J.S. (登録日: 2017-06-16, 公開日: 2018-01-03, 最終更新日: 2024-01-17)

• 主引用文献: Goffin, E.,Drapier, T.,Larsen, A.P.,Geubelle, P.,Ptak, C.P.,Laulumaa, S.,Rovinskaja, K.,Gilissen, J.,Tullio, P.,Olsen, L.,Frydenvang, K.,Pirotte, B.,Hanson, J.,Oswald, R.E.,Kastrup, J.S.,Francotte, P.; 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency.; J. Med. Chem., 61:251-264, 2018; PubMed: 29256599; DOI: 10.1021/acs.jmedchem.7b01323

実験手法

X-RAY DIFFRACTION (1.78 Å)