5O8F

Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone

Summary for 5O8F

• Entry DOI: 10.2210/pdb5o8f/pdb
• Descriptor: Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5, Nanobody Nb25, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: gabaa receptor, pregnanolone, nanobody complex, neurosteroid, ion channel, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 285317.35

Authors

Miller, P.S.,Scott, S.,Masiulis, S.,De Colibus, L.,Pardon, E.,Steyaert, J.,Aricescu, A.R. (deposition date: 2017-06-13, release date: 2017-11-01, Last modification date: 2024-01-17)

• Primary citation: Miller, P.S.,Scott, S.,Masiulis, S.,De Colibus, L.,Pardon, E.,Steyaert, J.,Aricescu, A.R.; Structural basis for GABAA receptor potentiation by neurosteroids.; Nat. Struct. Mol. Biol., 24:986-992, 2017; PubMed: 28991263; DOI: 10.1038/nsmb.3484

Experimental method

X-RAY DIFFRACTION (3.2 Å)