5O7I

ERK5 in complex with a pyrrole inhibitor

5O7I の概要

• エントリーDOI: 10.2210/pdb5o7i/pdb
• 分子名称: Mitogen-activated protein kinase 7, 4-(2-bromanyl-6-fluoranyl-phenyl)carbonyl-~{N}-pyridin-3-yl-1~{H}-pyrrole-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, pyrrole, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41523.56

構造登録者

Tucker, J.A.,Heptinstall, A.,Myers, S. (登録日: 2017-06-08, 公開日: 2018-06-20, 最終更新日: 2024-01-17)

• 主引用文献: Myers, S.M.,Miller, D.C.,Molyneux, L.,Arasta, M.,Bawn, R.H.,Blackburn, T.J.,Cook, S.J.,Edwards, N.,Endicott, J.A.,Golding, B.T.,Griffin, R.J.,Hammonds, T.,Hardcastle, I.R.,Harnor, S.J.,Heptinstall, A.B.,Lochhead, P.A.,Martin, M.P.,Martin, N.C.,Newell, D.R.,Owen, P.J.,Pang, L.C.,Reuillon, T.,Rigoreau, L.J.M.,Thomas, H.D.,Tucker, J.A.,Wang, L.Z.,Wong, A.C.,Noble, M.E.M.,Wedge, S.R.,Cano, C.; Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38 alpha and BRD4.; Eur.J.Med.Chem., 178:530-543, 2019; PubMed: 31212132; DOI: 10.1016/j.ejmech.2019.05.057

実験手法

X-RAY DIFFRACTION (2.38 Å)