5O7A
Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin
Summary for 5O7A
Entry DOI | 10.2210/pdb5o7a/pdb |
Descriptor | Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (10 entities in total) |
Functional Keywords | microtubules, tubulin, colchicine, quinolin-6-yloxyacetamides, motor protein |
Biological source | Rattus norvegicus (Norway Rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 264877.29 |
Authors | |
Primary citation | Sharma, A.,Saez-Calvo, G.,Olieric, N.,de Asis Balaguer, F.,Barasoain, I.,Lamberth, C.,Diaz, J.F.,Steinmetz, M.O. Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin. Int J Mol Sci, 18:-, 2017 Cited by PubMed: 28640209DOI: 10.3390/ijms18071336 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.495 Å) |
Structure validation
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