5O7A

Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin

Summary for 5O7A

• Entry DOI: 10.2210/pdb5o7a/pdb
• Descriptor: Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (10 entities in total)
• Functional Keywords: microtubules, tubulin, colchicine, quinolin-6-yloxyacetamides, motor protein
• Biological source: Rattus norvegicus (Norway Rat); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 264877.29

Authors

Sharma, A.,Olieric, N.,Steinmetz, M.O. (deposition date: 2017-06-08, release date: 2017-07-05)

• Primary citation: Sharma, A.,Saez-Calvo, G.,Olieric, N.,de Asis Balaguer, F.,Barasoain, I.,Lamberth, C.,Diaz, J.F.,Steinmetz, M.O.; Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.; Int J Mol Sci, 18:-, 2017; PubMed: 28640209; DOI: 10.3390/ijms18071336

Experimental method

X-RAY DIFFRACTION (2.495 Å)