5O6X

17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal quinoline based inhibitor

5O6X の概要

• エントリーDOI: 10.2210/pdb5o6x/pdb
• 分子名称: 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: non-steroidal inhibitor, 17beta-hsd14, 2, 6-pyridinketone inhibitors, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29830.59

構造登録者

Bertoletti, N.,Braun, F.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. (登録日: 2017-06-07, 公開日: 2018-06-06, 最終更新日: 2024-01-17)

• 主引用文献: Braun, F.,Bertoletti, N.,Moller, G.,Adamski, J.,Frotscher, M.,Guragossian, N.,Madeira Girio, P.A.,Le Borgne, M.,Ettouati, L.,Falson, P.,Muller, S.,Vollmer, G.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S.; Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.; Eur J Med Chem, 155:61-76, 2018; PubMed: 29859505; DOI: 10.1016/j.ejmech.2018.05.029

実験手法

X-RAY DIFFRACTION (1.35 Å)