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5O5H

Crystal structure of the human BRPF1 bromodomain in complex with BZ053

Summary for 5O5H
Entry DOI10.2210/pdb5o5h/pdb
DescriptorPeregrin, ~{N}-[6-(4-chloranylphenoxy)pyridin-3-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide, NITRATE ION, ... (4 entities in total)
Functional Keywordsbromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight14453.23
Authors
Zhu, J.,Caflisch, A. (deposition date: 2017-06-01, release date: 2018-06-13, Last modification date: 2024-01-17)
Primary citationZhu, J.,Zhou, C.,Caflisch, A.
Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem, 155:337-352, 2018
Cited by
PubMed: 29902720
DOI: 10.1016/j.ejmech.2018.05.037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

217705

數據於2024-03-27公開中

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