5O5H

Crystal structure of the human BRPF1 bromodomain in complex with BZ053

5O5H の概要

• エントリーDOI: 10.2210/pdb5o5h/pdb
• 分子名称: Peregrin, ~{N}-[6-(4-chloranylphenoxy)pyridin-3-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide, NITRATE ION, ... (4 entities in total)
• 機能のキーワード: bromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14453.23

構造登録者

Zhu, J.,Caflisch, A. (登録日: 2017-06-01, 公開日: 2018-06-13, 最終更新日: 2024-01-17)

• 主引用文献: Zhu, J.,Zhou, C.,Caflisch, A.; Structure-based discovery of selective BRPF1 bromodomain inhibitors.; Eur J Med Chem, 155:337-352, 2018; PubMed: 29902720; DOI: 10.1016/j.ejmech.2018.05.037

実験手法

X-RAY DIFFRACTION (1.85 Å)