5O55
Crystal structure of the human BRPF1 bromodomain in complex with BZ047
Summary for 5O55
Entry DOI | 10.2210/pdb5o55/pdb |
Descriptor | Peregrin, NITRATE ION, ~{N}-[(1~{S})-1-(1,5-dimethylpyrazol-4-yl)ethyl]-1-ethyl-3-methyl-2-oxidanylidene-quinoxaline-6-carboxamide, ... (4 entities in total) |
Functional Keywords | bromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14119.12 |
Authors | Zhu, J.,Caflisch, A. (deposition date: 2017-05-31, release date: 2018-06-13, Last modification date: 2024-01-17) |
Primary citation | Zhu, J.,Zhou, C.,Caflisch, A. Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155:337-352, 2018 Cited by PubMed: 29902720DOI: 10.1016/j.ejmech.2018.05.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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