5O49

Human FGF in complex with a covalent inhibitor

Summary for 5O49

• Entry DOI: 10.2210/pdb5o49/pdb
• Descriptor: Fibroblast growth factor receptor 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 3-fluorosulfonylbenzoate, SULFATE ION, ... (4 entities in total)
• Functional Keywords: fgfr fibroblast growth factor, covalent inhibition, fgfr fibroblast grwth fctr rtk, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P11362
• Total number of polymer chains: 2
• Total formula weight: 71465.67

Authors

Debreczeni, J.,Breed, J.,Mukherjee, H.,Aquila, B.,Kaiser, C.,Tentarelli, S.,Whitty, A.,Grimster, N. (deposition date: 2017-05-26, release date: 2018-02-07)

• Primary citation: Mukherjee, H.,Debreczeni, J.,Breed, J.,Tentarelli, S.,Aquila, B.,Dowling, J.E.,Whitty, A.,Grimster, N.P.; A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.; Org. Biomol. Chem., 15:9685-9695, 2017; PubMed: 29119993; DOI: 10.1039/c7ob02028g

Experimental method

X-RAY DIFFRACTION (1.91 Å)