5O49

Human FGF in complex with a covalent inhibitor

5O49 の概要

• エントリーDOI: 10.2210/pdb5o49/pdb
• 分子名称: Fibroblast growth factor receptor 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 3-fluorosulfonylbenzoate, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: fgfr fibroblast growth factor, covalent inhibition, fgfr fibroblast grwth fctr rtk, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P11362
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71465.67

構造登録者

Debreczeni, J.,Breed, J.,Mukherjee, H.,Aquila, B.,Kaiser, C.,Tentarelli, S.,Whitty, A.,Grimster, N. (登録日: 2017-05-26, 公開日: 2018-02-07)

• 主引用文献: Mukherjee, H.,Debreczeni, J.,Breed, J.,Tentarelli, S.,Aquila, B.,Dowling, J.E.,Whitty, A.,Grimster, N.P.; A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.; Org. Biomol. Chem., 15:9685-9695, 2017; PubMed: 29119993; DOI: 10.1039/c7ob02028g

実験手法

X-RAY DIFFRACTION (1.91 Å)