5O48

P.vivax NMT with an aminomethylindazole inhibitor bound

Summary for 5O48

Entry DOI	10.2210/pdb5o48/pdb
Related	5O4V
Descriptor	Glycylpeptide N-tetradecanoyltransferase, 2-oxopentadecyl-CoA, 1-[5-(4-fluoranyl-2-methyl-phenyl)-1~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, ... (8 entities in total)
Functional Keywords	transferase, inhibitor, myristoyl
Biological source	Plasmodium vivax
Total number of polymer chains	3
Total formula weight	140193.04
Authors	Brannigan, J.A.,Wilkinson, A.J. (deposition date: 2017-05-26, release date: 2018-05-16, Last modification date: 2018-07-04)
Primary citation	Mousnier, A.,Bell, A.S.,Swieboda, D.P.,Morales-Sanfrutos, J.,Perez-Dorado, I.,Brannigan, J.A.,Newman, J.,Ritzefeld, M.,Hutton, J.A.,Guedan, A.,Asfor, A.S.,Robinson, S.W.,Hopkins-Navratilova, I.,Wilkinson, A.J.,Johnston, S.L.,Leatherbarrow, R.J.,Tuthill, T.J.,Solari, R.,Tate, E.W. Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nat Chem, 10:599-606, 2018 Cited by PubMed: 29760414 DOI: 10.1038/s41557-018-0039-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation