5O45

Structure of human PD-L1 in complex with inhibitor

Summary for 5O45

• Entry DOI: 10.2210/pdb5o45/pdb
• Descriptor: Programmed cell death 1 ligand 1, PHE-MEA-9KK-SAR-ASP-VAL-MEA-TYR-SAR-TRP-TYR-LEU-CCS-GLY-NH2 (3 entities in total)
• Functional Keywords: pd-1, programmed death 1, pd-l1, programmed death ligand 1, immune checkpoint, cancer, cell cycle
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Endomembrane system ; Single-pass type I membrane protein : Q9NZQ7
• Total number of polymer chains: 2
• Total formula weight: 16605.96

Authors

Magiera, K.,Grudnik, P.,Dubin, G.,Holak, T.A. (deposition date: 2017-05-26, release date: 2017-09-20, Last modification date: 2024-01-17)

• Primary citation: Magiera-Mularz, K.,Skalniak, L.,Zak, K.M.,Musielak, B.,Rudzinska-Szostak, E.,Kocik, J.,Grudnik, P.,Sala, D.,Zarganes-Tzitzikas, T.,Shaabani, S.,Domling, A.,Dubin, G.,Holak, T.A.; Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.; Angew. Chem. Int. Ed. Engl., 56:13732-13735, 2017; PubMed: 28881104; DOI: 10.1002/anie.201707707

Experimental method

X-RAY DIFFRACTION (0.99 Å)