5O3G
Human Brd2(BD2) mutant in complex with AL-Am1
Summary for 5O3G
Entry DOI | 10.2210/pdb5o3g/pdb |
Descriptor | Bromodomain-containing protein 2, (2~{R})-2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-~{N}-ethyl-pent-4-enamide (3 entities in total) |
Functional Keywords | the bromodomain and extra-terminal domain (bet) family chromatin binding protein, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P25440 |
Total number of polymer chains | 2 |
Total formula weight | 27650.68 |
Authors | Chan, K.-H.,Runcie, A.C.,Ciulli, A. (deposition date: 2017-05-23, release date: 2018-02-14, Last modification date: 2024-01-17) |
Primary citation | Runcie, A.C.,Zengerle, M.,Chan, K.H.,Testa, A.,van Beurden, L.,Baud, M.G.J.,Epemolu, O.,Ellis, L.C.J.,Read, K.D.,Coulthard, V.,Brien, A.,Ciulli, A. Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition. Chem Sci, 9:2452-2468, 2018 Cited by PubMed: 29732121DOI: 10.1039/c7sc02536j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report