5O3G

Human Brd2(BD2) mutant in complex with AL-Am1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bromodomain-containing protein 2	polymer	114	13361.4	2	UniProt (P25440) Pfam (PF00439)	Homo sapiens (Human)	O27.1.1,Really interesting new gene 3 protein
2	C, D (A, B)	(2~{R})-2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-~{N}-ethyl-pent-4-enamide	non-polymer		464.0	2	Chemie (9J8)
3	E, F (A, B)	water	water		18.0	196	Chemie (HOH)

Sequence modifications

A, B: 344 - 455 (UniProt: P25440)

PDB	External Database	Details
Ser 342	-	expression tag
Met 343	-	expression tag
Val 383	Leu 383	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	26722.8
Non-Polymers*	Number of molecules	2
	Total formula weight	927.9
All*	Total formula weight	27650.7

*Water molecules are not included.