5O13
Crystal structure of PIM1 kinase in complex with small-molecule inhibitor
Summary for 5O13
Entry DOI | 10.2210/pdb5o13/pdb |
Descriptor | Serine/threonine-protein kinase pim-1, (3~{E})-5-chloranyl-3-[[5-[3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phenyl]furan-2-yl]methylidene]-1~{H}-indol-2-one, IMIDAZOLE, ... (5 entities in total) |
Functional Keywords | kinase, pim1, cx-6258, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35040.35 |
Authors | Dubin, G.,Bogusz, J. (deposition date: 2017-05-17, release date: 2017-11-01, Last modification date: 2024-01-17) |
Primary citation | Bogusz, J.,Zrubek, K.,Rembacz, K.P.,Grudnik, P.,Golik, P.,Romanowska, M.,Wladyka, B.,Dubin, G. Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors. Sci Rep, 7:13399-13399, 2017 Cited by PubMed: 29042609DOI: 10.1038/s41598-017-13557-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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