5O0U

Crystal structure of tarantula venom peptide Protoxin-II

Summary for 5O0U

Entry DOI	10.2210/pdb5o0u/pdb
Descriptor	Beta/omega-theraphotoxin-Tp2a, CHLORIDE ION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	inhibitor cystine knot, ion channel inhibitors, venom, toxin
Biological source	Thrixopelma pruriens (green velvet)
Total number of polymer chains	1
Total formula weight	4034.73
Authors	Tabor, A.,McCarthy, S.,Reyes, F.E. (deposition date: 2017-05-17, release date: 2017-09-13, Last modification date: 2019-03-27)
Primary citation	Wright, Z.V.F.,McCarthy, S.,Dickman, R.,Reyes, F.E.,Sanchez-Martinez, S.,Cryar, A.,Kilford, I.,Hall, A.,Takle, A.K.,Topf, M.,Gonen, T.,Thalassinos, K.,Tabor, A.B. The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7. J.Am.Chem.Soc., 139:13063-13075, 2017 Cited by PubMed: 28880078 DOI: 10.1021/jacs.7b06506 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.99 Å)

Structure validation