5NZO

Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 1-methyl-3-phenyl-1H-pyrazol-5-amine

5NZO の概要

• エントリーDOI: 10.2210/pdb5nzo/pdb
• 分子名称: D-3-phosphoglycerate dehydrogenase, 2-methyl-5-phenyl-pyrazol-3-amine (3 entities in total)
• 機能のキーワード: dehydrogenase, serine metabolism, fbdd, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42250.64

構造登録者

Unterlass, J.E.,Basle, A.,Blackburn, T.J.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. (登録日: 2017-05-14, 公開日: 2017-06-14, 最終更新日: 2024-01-17)

• 主引用文献: Unterlass, J.E.,Basle, A.,Blackburn, T.J.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J.; Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.; Oncotarget, 9:13139-13153, 2018; PubMed: 29568346; DOI: 10.18632/oncotarget.11487

実験手法

X-RAY DIFFRACTION (1.29 Å)