5NX9

Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL) in complex with its products AMP and fumarate

Summary for 5NX9

Entry DOI	10.2210/pdb5nx9/pdb
Descriptor	Adenylosuccinate lyase, CHLORIDE ION, ADENOSINE MONOPHOSPHATE, ... (8 entities in total)
Functional Keywords	adenylosuccinate lyase, fumarase, lyase
Biological source	Homo sapiens neanderthalensis
Total number of polymer chains	4
Total formula weight	224403.32
Authors	Van Laer, B.,Kapp, U.,Soler-Lopez, M.,Leonard, G.,Mueller-Dieckmann, C. (deposition date: 2017-05-09, release date: 2018-05-30, Last modification date: 2024-01-17)
Primary citation	Van Laer, B.,Kapp, U.,Soler-Lopez, M.,Moczulska, K.,Paabo, S.,Leonard, G.,Mueller-Dieckmann, C. Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase. Sci Rep, 8:18008-18008, 2018 Cited by PubMed: 30573755 DOI: 10.1038/s41598-018-36195-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation