5NWZ

FIBROBLAST GROWTH FACTOR RECEPTOR 4 KINASE DOMAIN (449-753) IN COMPLEX WITH IRREVERSIBLE LIGAND CGA159527

5NWZ の概要

• エントリーDOI: 10.2210/pdb5nwz/pdb
• 分子名称: Fibroblast growth factor receptor 4, ~{N}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{H}-pyrazol-5-yl]-2-(propanoylamino)benzamide (3 entities in total)
• 機能のキーワード: hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69582.34

構造登録者

Zou, C. (登録日: 2017-05-09, 公開日: 2018-04-04, 最終更新日: 2018-08-29)

• 主引用文献: Fairhurst, R.A.,Knoepfel, T.,Leblanc, C.,Buschmann, N.,Gaul, C.,Blank, J.,Galuba, I.,Trappe, J.,Zou, C.,Voshol, J.,Genick, C.,Brunet-Lefeuvre, P.,Bitsch, F.,Graus-Porta, D.,Furet, P.; Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region.; Medchemcomm, 8:1604-1613, 2017; PubMed: 30108871; DOI: 10.1039/c7md00213k

実験手法

X-RAY DIFFRACTION (2.37 Å)