5NWE

Complex of H275Y mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir

5NWE の概要

• エントリーDOI: 10.2210/pdb5nwe/pdb
• 関連するPDBエントリー: 5NZ4 5NZE 5NZF 5NZN
• 分子名称: Neuraminidase, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: neuraminidase, influenza, hydrolase
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 175999.96

構造登録者

Pachl, P.,Pokorna, J. (登録日: 2017-05-05, 公開日: 2018-07-04, 最終更新日: 2024-01-17)

• 主引用文献: Pokorna, J.,Pachl, P.,Karlukova, E.,Hejdanek, J.,Rezacova, P.,Machara, A.,Hudlicky, J.,Konvalinka, J.,Kozisek, M.; Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus.; Viruses, 10:-, 2018; PubMed: 29933553; DOI: 10.3390/v10070339

実験手法

X-RAY DIFFRACTION (2 Å)