5NUD

FIBROBLAST GROWTH FACTOR RECEPTOR 4 KINASE DOMAIN (449-753) IN COMPLEX WITH IRREVERSIBLE LIGAND CGA159527

Summary for 5NUD

Entry DOI	10.2210/pdb5nud/pdb
Descriptor	Fibroblast growth factor receptor 4, 3-chloranyl-~{N}-(3-nitropyridin-2-yl)-5-(trifluoromethyl)pyridin-2-amine (3 entities in total)
Functional Keywords	other, hormone-growth factor complex, hormone/growth factor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	69374.66
Authors	Zou, C. (deposition date: 2017-04-29, release date: 2018-04-04, Last modification date: 2018-08-29)
Primary citation	Fairhurst, R.A.,Knoepfel, T.,Leblanc, C.,Buschmann, N.,Gaul, C.,Blank, J.,Galuba, I.,Trappe, J.,Zou, C.,Voshol, J.,Genick, C.,Brunet-Lefeuvre, P.,Bitsch, F.,Graus-Porta, D.,Furet, P. Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region. Medchemcomm, 8:1604-1613, 2017 Cited by PubMed: 30108871 DOI: 10.1039/c7md00213k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation