5NU5
Crystal structure of the human bromodomain of EP300 bound to the inhibitor XDM-CBP
Summary for 5NU5
Entry DOI | 10.2210/pdb5nu5/pdb |
Descriptor | Histone acetyltransferase p300, ~{N}-[[2,8-bis(oxidanyl)naphthalen-1-yl]methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, protein-inhibitor complex, epigenetics, ep300, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q09472 |
Total number of polymer chains | 2 |
Total formula weight | 28696.75 |
Authors | Huegle, M.,Wohlwend, D. (deposition date: 2017-04-28, release date: 2017-08-16, Last modification date: 2024-01-17) |
Primary citation | Hugle, M.,Lucas, X.,Ostrovskyi, D.,Regenass, P.,Gerhardt, S.,Einsle, O.,Hau, M.,Jung, M.,Breit, B.,Gunther, S.,Wohlwend, D. Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56:12476-12480, 2017 Cited by PubMed: 28766825DOI: 10.1002/anie.201705516 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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