5NTK

Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds

Summary for 5NTK

Entry DOI	10.2210/pdb5ntk/pdb
Descriptor	Nuclear receptor ROR-gamma, [(3~{S},8~{S},9~{S},10~{R},13~{R},14~{S},17~{R})-10,13-dimethyl-17-[(2~{R})-5-[[4-(2-morpholin-4-ylethoxy)phenyl]methylamino]-5-oxidanylidene-pentan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate (3 entities in total)
Functional Keywords	nuclear hormone receptor, ligand-binding domain, inverse agonist, nuclear protein
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P51449
Total number of polymer chains	2
Total formula weight	54953.72
Authors	Kallen, J. (deposition date: 2017-04-28, release date: 2017-06-21, Last modification date: 2024-01-17)
Primary citation	Kallen, J.,Izaac, A.,Be, C.,Arista, L.,Orain, D.,Kaupmann, K.,Guntermann, C.,Hoegenauer, K.,Hintermann, S. Structural States of ROR gamma t: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds. ChemMedChem, 12:1014-1021, 2017 Cited by PubMed: 28590087 DOI: 10.1002/cmdc.201700278 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation