5NT1

Complex of influenza A NS1 effector domain with TRIM25 coiled coil

Summary for 5NT1

DescriptorE3 ubiquitin/ISG15 ligase TRIM25, Non-structural protein 1 (3 entities in total)
Functional Keywordsviral protein/host protein, ligase
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm  Q14258
Host nucleus  P03496
Total number of polymer chains6
Total molecular weight117289.85
Authors
Koliopoulos, M.G.,Rittinger, K. (deposition date: 2017-04-27, release date: 2018-05-16, Last modification date: 2018-05-23)
Primary citation
Koliopoulos, M.G.,Lethier, M.,van der Veen, A.G.,Haubrich, K.,Hennig, J.,Kowalinski, E.,Stevens, R.V.,Martin, S.R.,Reis E Sousa, C.,Cusack, S.,Rittinger, K.
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9:1820-1820, 2018
PubMed: 29739942 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-04214-8
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.82 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22640.7%2.3%5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5nt1
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Molmil generated image of 5nt1
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Molmil generated image of 5nt1
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