5NQW

IgE-Fc in complex with single domain antibody 026

5NQW の概要

• エントリーDOI: 10.2210/pdb5nqw/pdb
• 分子名称: Immunoglobulin heavy constant epsilon, 026, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: ige-fc, nanobody, vhh, allergy, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 79828.77

構造登録者

Laursen, N.S.,Jabs, F.,Spillner, E.,Andersen, G.R. (登録日: 2017-04-21, 公開日: 2018-01-17, 最終更新日: 2024-01-17)

• 主引用文献: Jabs, F.,Plum, M.,Laursen, N.S.,Jensen, R.K.,Molgaard, B.,Miehe, M.,Mandolesi, M.,Rauber, M.M.,Pfutzner, W.,Jakob, T.,Mobs, C.,Andersen, G.R.,Spillner, E.; Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts Fc epsilon RI interaction.; Nat Commun, 9:7-7, 2018; PubMed: 29295972; DOI: 10.1038/s41467-017-02312-7

実験手法

X-RAY DIFFRACTION (3.4 Å)